Director of Office of the CEO, BillionToOne

• The ideal candidate is a first-principles thinker, a builder, AI-native, and exceptionally sharp. You have founded a company, operated at the most senior level of a top scaleup, or built a track record of high-impact strategic work, and you are looking for your next high-leverage seat — one that gives you scale, mission, and direct CEO exposure without starting from scratch
• 6-10+ years of building or operating experience, with a track record of exceptional impact in entrepreneurial or builder-oriented environments
• One of the following backgrounds: founder of a company that has since been acquired, wound down, or moved on from; senior executive (COO, CPO, VP-level) who joined a top scaleup as one of its first 5 to 10 employees; or top-tier management consultant from MBB or a top boutique firm with healthcare or life sciences exposure, with some operational experience under your belt
• First-principles thinker with exceptional analytical horsepower
• Builder mentality — bias to action, comfort with ambiguity, ability to operate without a playbook
• AI-native fluency in using AI tools to move faster and amplify individual leverage
• Strong written and verbal communication, including with executives and the Board
• Genuine interest in molecular diagnostics and the BillionToOne mission
• On-site position (relocation to SF Bay Area required)

Desirable

• We are seeking exceptional entrepreneurial builders to join BillionToOne's newly launched Founder in Residence Program as a Director, Office of the CEO. In this 12 to 18 month program, you will work directly with the CEO and Chief of Staff on the company's highest-priority strategic and operational projects, and graduate into a permanent senior operating role at the Director or Senior Director level
• This is one of the highest-leverage roles at BillionToOne. You will be deployed onto a portfolio of high-impact projects each quarter — from new product launches, to commercial strategy, to operational turnarounds, to incubating new business lines and capabilities. Your portfolio of 1-2 projects will be revisited each quarter so you are always working on what matters most to the company
• This role is a hybrid (onsite 3 days/week) position and reports directly to the VP of Business Operations and Chief of Staff, with active co-sponsorship from the CEO
• Own CEO-Priority Projects: Lead one or more of BillionToOne's highest-priority strategic and operational initiatives each quarter, sourced directly from the CEO and Office of the CEO. Project types span new product launch support, commercial and go-to-market strategy, business development, operational excellence, competitive response, and the incubation of new business lines
• Find Broken Things and Fix Them: Identify under-performing processes, workflows, or functions. Diagnose root cause, design the fix, and drive execution end-to-end with cross-functional teams
• Cross-Functional Leadership: Lead and influence cross-functional teams across Sales, Product, Lab Operations, Compliance, Reimbursement, Finance, BD, Legal, and HR. Build deep working knowledge of how each function operates through the projects you lead
• Operate with AI: Drive results in ambiguous, fast-moving environments. Use first-principles thinking and AI-native fluency to move faster than the company would otherwise be able to
• CEO and Executive Partnership: Participate in CEO meetings, present to the executive team on an ongoing basis, and serve as a trusted thought partner to the CEO and Chief of Staff on company-shaping decisions