Senior Software Engineer, Personalis

Cloud Infrastructure

$150-180k

+ Annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity)

AWS

Docker

Kubernetes

GCP

Python

Bash

Linux

Terraform

Jenkins

Azure

Powershell

DevOps

Senior and Expert level

San Francisco Bay Area

More information about location

3 days a week in office (Fremont, CA)

Platform personalising cancer testing

Be an early applicant

Platform personalising cancer testing

201-500 employees

HealthcareB2BMachine Learning

Be an early applicant

$150-180k

+ Annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity)

AWS

Docker

Kubernetes

GCP

Python

Bash

Linux

Terraform

Jenkins

Azure

Powershell

DevOps

Senior and Expert level

San Francisco Bay Area

More information about location

3 days a week in office (Fremont, CA)

201-500 employees

HealthcareB2BMachine Learning

Company mission

To transform the development of next-generation therapies by providing more comprehensive molecular data about each patient’s cancer and immune response.

Job

Company

Role

Who you are

The ideal candidate has deep expertise in cloud technologies, Kubernetes, Docker, Infrastructure as Code (IaC), DevOps practices, and cloud security
Bachelor's degree in Computer Science, Information Technology, Engineering, or related field
7+ years of infrastructure engineering experience
5+ years of hands-on cloud engineering experience in AWS, Azure, or GCP
3+ years of Kubernetes administration and container platform management experience
Strong experience with Docker and containerized application deployment
Experience implementing Infrastructure as Code using Terraform or equivalent tools
Experience with Linux systems administration and cloud networking
Strong scripting and automation skills using Python, PowerShell, Bash, or similar languages
Experience supporting production-critical environments with high availability requirements
Cloud Architecture & Engineering
Kubernetes Administration
Docker & Container Platforms
Infrastructure Automation
DevOps & CI/CD
Cloud Security & Compliance
Site Reliability Engineering (SRE)
Disaster Recovery & Business Continuity
Technical Leadership
Problem Solving & Incident Management

What the job involves

We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud-first infrastructure platforms across AWS, Azure, and hybrid environments
This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems
This individual will work closely with software engineering, bioinformatics, security, laboratory operations, and compliance teams to ensure reliable and compliant infrastructure services supporting business-critical applications
Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments
Architect highly available, scalable, secure, and cost-effective cloud solutions
Implement cloud networking, identity management, storage, compute, monitoring, and security services
Support integration between cloud and on-premises infrastructure environments
Manage hybrid networking, VPNs, Direct Connect, ExpressRoute, and secure connectivity solutions
Support virtualization platforms and legacy infrastructure during cloud transformation initiatives
Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments
Administer container orchestration platforms including Amazon EKS, Azure AKS, or self-managed Kubernetes environments
Build and maintain containerized application platforms using Docker
Automate infrastructure provisioning, configuration management, and deployment processes
Support and optimize CI/CD pipelines using GitHub Actions, GitLab CI, Azure DevOps, Jenkins, or similar platforms
Implement automated monitoring, alerting, scaling, backup, and recovery solutions
Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable
Ensure secure management of Protected Health Information (PHI) and sensitive business data
Partner with software engineering teams to optimize cloud-native application architectures
Success Metrics:
Cloud platform availability and reliability
Kubernetes cluster health and operational efficiency
Infrastructure automation coverage and deployment success rates
Compliance with HIPAA, CLIA, CAP, and security requirements
Cloud cost optimization and resource utilization
Incident response and recovery performance
Successful delivery of cloud modernization initiatives
Security and audit readiness

Our take

Personalis is developing biopharmaceuticals for cancer immunotherapies, enabling the next generation of precision cancer therapies and diagnostics.

A leader in advanced cancer genomics, Personalis is evolving its understanding of cancer through the 'Personalis NeXT Platform®'. This provides biopharmaceutical customers and clinicians with information on approximately 20,000 human genes and the immune systems all from a single sample.

Through multiple funding rounds, including investors such as Stanford University, Lightspeed Venture Partners, Abingworth, and Merck, Personalis has obtained capital to grow its products and advance its knowledge in developing the next generation of cancer diagnostics.

Steph

Company Specialist at Welcome to the Jungle

Insights

Top investors

-13% employee growth in 12 months

Glassdoor (3.6)

Company

Funding (last 2 of 3 rounds)

Jan 2015

$33m

SERIES C

Oct 2013

$22m

SERIES B

Total funding: $75m

Company benefits

Medical insurance
401(k)
Commuter benefits

Company HQ

Fremont, CA

Leadership

Atul Butte

(Founder & Scientific Advisor)

Previously worked at Stanford University, School of Medicine as a Professor of Pediatrics and as a Chief, Division of Systems Medicine in the Department of Pediatrics.

Christopher (Chris) Hall

(President & CEO)

Joined the company in 2022 as SVP and Head of Diagnostic Business, becoming CEO in 2023. Formerly CEO at Naring Health, President and COO at Veracyte, and SVP at Celera.

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